While nuclear powers have not signed up to the treaty, activists who have pushed for its enactment hold out hope that it will nonetheless prove to be more than symbolic and have a gradual deterrent effect.
Honduras became the 50th country to ratify.
UN Secretary-General Antonio Guterres called it "the culmination of a worldwide movement to draw attention to the catastrophic humanitarian consequences of any use of nuclear weapons," according to a statement from his spokesman.
"It represents a meaningful commitment towards the total elimination of nuclear weapons, which remains the highest disarmament priority of the United Nations."
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